Pharmacology of Local Anesthetics
1. The factor that is LEAST likely to affect the onset of a local anesthetics is:
- pKa
- Tissue diffusion
- Protein binding
- Addition of sodium bicarbonate
- Concentration
2. Adding sodium bicarbonate to increase the pH of a local anesthetic produces a "carbonated local anesthetic."
- TRUE
- FALSE
3. Which of the following local anesthetics is most potent, least stabile, and most allergenic?
- Ropivacaine
- Lidocaine
- Tetracaine
- Prilocaine
- Mepivacaine
Toxicity of Local Anesthetics
4. Of the following, the local anesthetic with the LEAST neuro-toxic potential is:
- Lidocaine
- Tetracaine
- Bupivacaine
- Procaine
5. The reports of so-called transient radicular irritation (now referred to as "transient neurologic syndrome" following spinal anesthesia PROVES that certain local anesthetics are neuro-toxic.
- TRUE
- FALSE
Spinal Anesthesia
6. During spinal anesthesia, all of the following SIGNIFICANTLY influence the distribution of local anesthetic in the cerebrospinal fluid (CSF) EXCEPT:
- CSF circulation
- Dose
- Baricity
- Configuration of the spinal column
7. Cauda epuina syndrome following continuous spinal anesthesia occurs ONLY when spinal micro-catheters are used.
- TRUE
- FALSE
Epidural Anesthesia
8. The drug MOST LIKELY to be associated with spinal/epidural hematoma with central neuraxis blockade (spinal, epidural anesthesia), with or without a catheter is:
- Postoperative low molecular weight heparin
- Aspirin
- Postoperative coumadin
- Subcutaneous un-fractionated heparin
9. During epidural anesthesia, which of the following contains the HIGHEST concentration of local anesthetic:
- Dorsal root ganglia
- Cerebrospinal fluid
- Ventral horn
- Nerve roots
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